How To Perform Meaningful Estimates of Genetic Effects

How To Perform Meaningful Estimates of Genetic Effects

Although the genotype-phenotype map plays a central role both in Quantitative and Evolutionary Genetics, the formalization of a completely general and satisfactory model of genetic effects, particularly accounting for epistasis, remains a theoretical challenge. Here, we use a two-locus genetic system in simulated populations with epistasis to show the convenience of using a recently developed m...

Capturing Semantic Hierarchies to Perform Meaningful Integration in HTML Tables

We present a new approach that automatically captures the semantic hierarchies in HTML tables, and semi-automatically integrates HTML tables belonging to a domain. It first automatically captures the attribute-value pairs in HTML tables by normalization and recognizing their headings. After generating global schema manually, it learns the lexical semantic sets and contexts, by which it then eli...

How to perform an amniocentesis.

Amniocentesis is a technique for withdrawing amniotic fluid from the uterine cavity using a needle, via a transabdominal approach and under continuous ultrasound guidance, in order to obtain a sample of fetal exfoliated cells, transudates, urine or secretions. It can be performed from 16 weeks of pregnancy onwards, with various chromosomal, biochemical, molecular and microbial studies being per...

How to perform picture-perfect respiratory assessment.

How to perform pulmonary vein isolation.

The advent of technology for the delivery of radiofrequency energy via electrode catheters, in the late 1980s, led to the perfection of techniques for the ablation of accessory pathways and classical flutter [1e4]. This has been so successful that these substrates for arrhythmia are rarely seen in the Western world. Two major arrhythmias, however, still remain to be conquereddatrial fibrillatio...